Diethylcarbamazine in the control of bancroftian filariasis in the Ok Tedi area of Papua New Guinea: phase 2--annual single-dose treatment.
Identifieur interne : 00C857 ( Main/Exploration ); précédent : 00C856; suivant : 00C858Diethylcarbamazine in the control of bancroftian filariasis in the Ok Tedi area of Papua New Guinea: phase 2--annual single-dose treatment.
Auteurs : G J Schuurkamp [Papouasie-Nouvelle-Guinée] ; R K Kereu ; P K Bulungol ; A. Kawereng ; P E SpicerSource :
- Papua and New Guinea medical journal [ 0031-1480 ] ; 1994.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Calendrier d'administration des médicaments, Diéthylcarbamazine (administration et posologie), Diéthylcarbamazine (usage thérapeutique), Enfant, Enfant d'âge préscolaire, Filariose lymphatique (), Filariose lymphatique (parasitologie), Filariose lymphatique (traitement médicamenteux), Filariose lymphatique (épidémiologie), Humains, Paludisme (épidémiologie), Papouasie - Nouvelle-Guinée (épidémiologie), Résultat thérapeutique, Splénomégalie (parasitologie), Wuchereria bancrofti.
- MESH :
- administration et posologie : Diéthylcarbamazine.
- parasitologie : Filariose lymphatique, Splénomégalie.
- traitement médicamenteux : Filariose lymphatique.
- usage thérapeutique : Diéthylcarbamazine.
- épidémiologie : Filariose lymphatique, Paludisme, Papouasie - Nouvelle-Guinée.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Calendrier d'administration des médicaments, Enfant, Enfant d'âge préscolaire, Filariose lymphatique, Humains, Résultat thérapeutique, Wuchereria bancrofti.
- Wicri :
- geographic : Papouasie-Nouvelle-Guinée.
English descriptors
- KwdEn :
- Adolescent, Adult, Animals, Child, Child, Preschool, Diethylcarbamazine (administration & dosage), Diethylcarbamazine (therapeutic use), Drug Administration Schedule, Elephantiasis, Filarial (complications), Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (epidemiology), Elephantiasis, Filarial (parasitology), Humans, Malaria (epidemiology), Middle Aged, Papua New Guinea (epidemiology), Splenomegaly (parasitology), Treatment Outcome, Wuchereria bancrofti.
- MESH :
- chemical , administration & dosage : Diethylcarbamazine.
- chemical , therapeutic use : Diethylcarbamazine.
- geographic , epidemiology : Papua New Guinea.
- complications : Elephantiasis, Filarial.
- drug therapy : Elephantiasis, Filarial.
- epidemiology : Elephantiasis, Filarial, Malaria.
- parasitology : Elephantiasis, Filarial, Splenomegaly.
- Adolescent, Adult, Animals, Child, Child, Preschool, Drug Administration Schedule, Humans, Middle Aged, Treatment Outcome, Wuchereria bancrofti.
Abstract
The Phase 1 semiannual single-dose 6 mg/kg diethylcarbamazine (DEC) treatment program demonstrated a significant reduction for Wuchereria bancrofti in the Ok Tedi area of Western Province, Papua New Guinea. The rate of detectable microfilaraemia was effectively reduced from 39% to 11% and mean microfilarial (mf) densities from 79mf/20 microliters to 19mf/20 microliters. The Phase 2 annual single-dose treatment of 6mg/kg DEC not only maintained the gains made during Phase 1 but reduced the microfilaraemia rate to less than 5% by 1990, with mf densities remaining stable at less than 20mf/20 microliters, amongst all participating villagers screened within the 5 original villages. The annual treatment program was expanded into 7 remote villages not subject to any form of active vector control. The microfilaraemia rate in these villages declined from 41% before treatment to 17% after only two annual administrations of 6mg/kg DEC, and mf blood densities were reduced from 71mf/20 microliters to 20mf/20 microliters. As was observed in the 5 original villages participating in the program, a significant reduction in splenomegaly associated with the DEC treatment was reported for the 7 villages in the expanded program during Phase 2; enlarged spleen rates were reduced from 50% (1986) to 32% (1990) and from 76% (1988) to 48% (1990), respectively. Malaria rates on the other hand increased slightly or remained stable. Malaria infections associated with W. bancrofti (mixed parasite infections) stimulated a greater splenic response than either parasite detected on its own.
PubMed: 7771117
Affiliations:
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Le document en format XML
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Kawereng</name></author><author><name sortKey="Spicer, P E" sort="Spicer, P E" uniqKey="Spicer P" first="P E" last="Spicer">P E Spicer</name></author></analytic><series><title level="j">Papua and New Guinea medical journal</title><idno type="ISSN">0031-1480</idno><imprint><date when="1994" type="published">1994</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Child</term><term>Child, Preschool</term><term>Diethylcarbamazine (administration & dosage)</term><term>Diethylcarbamazine (therapeutic use)</term><term>Drug Administration Schedule</term><term>Elephantiasis, Filarial (complications)</term><term>Elephantiasis, Filarial (drug therapy)</term><term>Elephantiasis, Filarial (epidemiology)</term><term>Elephantiasis, Filarial (parasitology)</term><term>Humans</term><term>Malaria (epidemiology)</term><term>Middle Aged</term><term>Papua New Guinea (epidemiology)</term><term>Splenomegaly (parasitology)</term><term>Treatment Outcome</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Calendrier d'administration des médicaments</term><term>Diéthylcarbamazine (administration et posologie)</term><term>Diéthylcarbamazine (usage thérapeutique)</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Filariose lymphatique ()</term><term>Filariose lymphatique (parasitologie)</term><term>Filariose lymphatique (traitement médicamenteux)</term><term>Filariose lymphatique (épidémiologie)</term><term>Humains</term><term>Paludisme (épidémiologie)</term><term>Papouasie - Nouvelle-Guinée (épidémiologie)</term><term>Résultat thérapeutique</term><term>Splénomégalie (parasitologie)</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Diethylcarbamazine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Diethylcarbamazine</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Papua New Guinea</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Diéthylcarbamazine</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Malaria</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Filariose lymphatique</term><term>Splénomégalie</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Splenomegaly</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Diéthylcarbamazine</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Filariose lymphatique</term><term>Paludisme</term><term>Papouasie - Nouvelle-Guinée</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Child</term><term>Child, Preschool</term><term>Drug Administration Schedule</term><term>Humans</term><term>Middle Aged</term><term>Treatment Outcome</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Calendrier d'administration des médicaments</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Filariose lymphatique</term><term>Humains</term><term>Résultat thérapeutique</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Papouasie-Nouvelle-Guinée</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The Phase 1 semiannual single-dose 6 mg/kg diethylcarbamazine (DEC) treatment program demonstrated a significant reduction for Wuchereria bancrofti in the Ok Tedi area of Western Province, Papua New Guinea. The rate of detectable microfilaraemia was effectively reduced from 39% to 11% and mean microfilarial (mf) densities from 79mf/20 microliters to 19mf/20 microliters. The Phase 2 annual single-dose treatment of 6mg/kg DEC not only maintained the gains made during Phase 1 but reduced the microfilaraemia rate to less than 5% by 1990, with mf densities remaining stable at less than 20mf/20 microliters, amongst all participating villagers screened within the 5 original villages. The annual treatment program was expanded into 7 remote villages not subject to any form of active vector control. The microfilaraemia rate in these villages declined from 41% before treatment to 17% after only two annual administrations of 6mg/kg DEC, and mf blood densities were reduced from 71mf/20 microliters to 20mf/20 microliters. As was observed in the 5 original villages participating in the program, a significant reduction in splenomegaly associated with the DEC treatment was reported for the 7 villages in the expanded program during Phase 2; enlarged spleen rates were reduced from 50% (1986) to 32% (1990) and from 76% (1988) to 48% (1990), respectively. Malaria rates on the other hand increased slightly or remained stable. Malaria infections associated with W. bancrofti (mixed parasite infections) stimulated a greater splenic response than either parasite detected on its own.</div></front></TEI><affiliations><list><country><li>Papouasie-Nouvelle-Guinée</li></country></list><tree><noCountry><name sortKey="Bulungol, P K" sort="Bulungol, P K" uniqKey="Bulungol P" first="P K" last="Bulungol">P K Bulungol</name><name sortKey="Kawereng, A" sort="Kawereng, A" uniqKey="Kawereng A" first="A" last="Kawereng">A. Kawereng</name><name sortKey="Kereu, R K" sort="Kereu, R K" uniqKey="Kereu R" first="R K" last="Kereu">R K Kereu</name><name sortKey="Spicer, P E" sort="Spicer, P E" uniqKey="Spicer P" first="P E" last="Spicer">P E Spicer</name></noCountry><country name="Papouasie-Nouvelle-Guinée"><noRegion><name sortKey="Schuurkamp, G J" sort="Schuurkamp, G J" uniqKey="Schuurkamp G" first="G J" last="Schuurkamp">G J Schuurkamp</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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